Effect of binder type and lubrication method on the binder efficacy for direct compression

The effect of different binders for direct compression on tablet critical quality attributes was investigated. Dicalcium phosphate, lactose and microcrystalline cellulose were used as fillers combined with ten (10, 20 30% w/w). Binder properties linked to tensile strength via partial least square analysis. Tablets containing VA64F PH105 exhibited the highest which their compaction (specific work compaction, elasticity, cohesion index) particle size. In contrast, S1500 E15 lowest all binders. Lubrication method influenced lubricant sensitivity observed some extent Tensile significantly higher applying external compared internal lubrication. Fast disintegration MCC (PH105 PH200) starch (S1500 NMSt) grades, whereas HPC (KEXF KEF) resulted in delayed disintegration. Wettability measurements, determination contact angle, correlated well behaviour can therefore be an indicative measurement This study revealed binder properties, filler type lubrication attributes. addition, potential dry addition highlighted.